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Randomly popped into my head this question. I can imagine the worst element would be trust. How would you trust anyone and what they're telling you?
Maybe... How could I tell?
But if you lost your memory you'd have no reason at all to doubt anyone, to begin with at least.
Not that I recall.
I can barely remember what I was doing 5 seconds ago most times 😁
But only real experience of this kind was my big bike smash and no memory of the smash or events after it until day and half later in hospital. Rambling concussed argument insisting I was going to drive home apparently, and being "uncooperative" at the hospital when they were trying to give me a scan. Only have what people have told me what happened to go on. Could have been abducted by aliens for all I know.
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It's the only way
Having no context for anything would be difficult, I’d expect. That said, memory is a broad spectrum, even just up to the short/long-term parts. There are some really detailed and interesting papers written on memory, not to mention a world of musing and observation on the subject by philosophers over the centuries. For example, the idea of DNA memory exists, where an individual contains, biologically, a memory which is related to their ancestors experience.
Another fascinating fact is related to the memory of butterflies. Scientitists were able to demonstrate that some butterflies retained memories (of sorts) from their pre-metamorphosis state. Caterpillars were given electric shocks to imprint certain smells, so the caterpillars would react with repulsion to those smells. They were tested again after they had transformed to butterflies and some of the insects were still repelled by the smells. Bearing in mind that a caterpillar’s brain and nervous system is essentially liquified in metamorphosis, these observations are quite remarkable.
I can imagine the worst element would be trust. How would you trust anyone and what they’re telling you?

Most Saturday nights when younger....
I don’t know
Lost memories of the two weeks before a crash where I had significant concussion. Pretty unpleasant and disorientating. Had to be re-introduced to new colleagues etc... Not my favourite experience.
Sometimes ,when riding very familiar routes, I completely lose myself for a moment or two and I haven’t a clue where I am.
Early onset?:-)
My brother had temporary memory loss after making a mistake on the diving boards at the local swimming pool. he was the most annoying prick in the world for 2 days until he recovered.
A couple of years later it happened again after I hit him very hard with a big heavy cushion we had on the settee at home.
Just the odd day here and there through drink.
About 24hr gone for good - around a road bike crash that left me unconscious
still, taught me to maintain my bike more carefully (and what threadlock was)
I put it down somewhere the other day, and I haven’t been able to find it since.
Actually, there’s roughly a week when I was in bed with flu, where I have little to no recollection at all, it’s just a blank space. That was thirty something years ago.