Antihistamine withd...
 

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Antihistamine withdrawal

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I’ve been on Xyzal (levocetirizene) for about 15 years. I was initially prescribed them for stress related urticaria.

My life stresses are very different to when I was prescribed them so I want to come off them. However,  I seem to be suffering quite severe histamine rebound.

Has anyone else been through this? How long does it last? I currently feel awful with the worst itchy skin I’ve ever experienced. I could easily make myself bleed and still not satisfy the itch.

A quick Google says 3-7 days is normal but I’ve also seen that it can last up to 3 weeks… I’m currently 6 days in without any reduction in itching. Help..!!!


 
Posted : 13/02/2025 3:55 pm
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I had a period of time a few years ago taking them for really dreadful itching. I wasn't on them for anywhere near as long as you have been though. One thing I noticed is that I could actually control the itching by complete concentration on it. I just couldn't do anything else at the same time as without total focus it came back. I didn't just stop taking them I just slowly increased the time between taking them. Might just be an hour later one day than the previous one. Over time it became every other day and then maybe a couple of times a week and then just when I felt it might be starting again. I've had no reoccurrence since and it must be 10 years ago now.  


 
Posted : 13/02/2025 4:06 pm
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That’s reassuring; I did taper slightly but not quite so regimented as you - I did every other day for a week then half a tablet for a few days without any major issues then went cold turkey. Wow..! This is far worse than the symptoms for which i was taking them. 


 
Posted : 13/02/2025 4:31 pm

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